Synthesis and biological activity of silicon-containing phosphorodithioates

Silylmethanethiols (RRMeSiCH2SH)-R-1-Me-2 smoothly undergo Mannich-type condensation reaction with O,O-dialkyl phosphorodithioates (RO)(2)P(S)SH and formaldehyde. By utilizing the above reaction and nucleophilic substitution of O,O-diethyl-S-(2-bromoethyl)phosphorodithioate with silylmethanethiols, 37 novel silicon-containing phosphorodithioates (RO)(2)P(S)S(CH2)(n)(SCH2SiMeRR2)-R-1 (n =1, 2) were synthesized. The bioassay results show that the main title compounds possess some insecticidal and acaricidal activities at the preliminary screening concentration.