RETRACTED: The role of fenhexamid on the proliferation of ovarian cancer BG-1 cells (Retracted Article)

被引：0

作者：

Fei, Anxing ^{[1
]}

Fu, Handong ^{[3
]}

Jiang, Hong ^{[1
,4
]}

Wei, Liping ^{[1
]}

Zhang, Hongxia ^{[1
]}

Fei, Anqiong ^{[2
]}

Zhang, Yan ^{[1
]}

Zou, Tiantian ^{[1
]}

Gao, Shuzhen ^{[1
]}

Li, Lin ^{[4
]}

Jiang, Hong ^{[1
,4
]}

Zhou, Min ^{[4
]}

Xing, Hui ^{[4
]}

Huang, Yanli ^{[4
]}

机构：

[1] Huangshi Maternal & Child Hlth Hosp, Clin Lab, Lab Dept, Huangshi 435000, Hubei, Peoples R China

[2] Daye Gen Hosp, Huangshi 435100, Hubei, Peoples R China

[3] Wuhan Univ Sci & Technol, Xiaogan Hosp, Xiaogan 432100, Hubei, Peoples R China

[4] Hubei Univ Arts & Sci, Xiangyang Cent Hosp, Dept Obstet & Gynecol, Xiangyang 441021, Hubei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2018年 / 11卷 / 04期

关键词：

Ovarian cancer; fenhexamid; pesticide residues; ESTROGEN-RECEPTOR-ALPHA; DEPENDENT SIGNALING PATHWAY; BISPHENOL-A; GROWTH; TRICLOSAN; MODELS; GENES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To study the influence of fenhexamid in pesticide residue to the human ovarian cancer BG-1 cell proliferation. Detecting the effectiveness of 17 beta-estradiol, fenhexamid and Fulvestrant to BG-1 cell proliferation by MTT, and detecting the expression levels of cyclin D1 and cyclin E by Western blot. Fenhexamid can promote BG-1 cell proliferation for its estrogen-like effect. On the other hand, it can help to improve the expression levels of cyclin D1 and cyclin E in BG-1 cells which is regulated by ER-dependent pathway. And 17 beta-estradiol is also regulated by the same way. The existence of fenhexamid can promote ovarian cancer cell proliferation, so for patients with ovarian cancer, fenhexamid in pesticide residue may make medical conditions worse.

引用

页码：2025 / 2031

页数：7

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