Anti-angiogenic therapies in prostate cancer

被引：7
|
作者：
Maria Martinez-Jabaloyas, Jose [1 ,2 ]
Antonio March-Villalba, Jose [1 ,2 ]
Mercedes Navarro-Garcia, Maria [1 ]
Dasi, Francisco [1 ,3 ]
机构：
[1] Univ Valencia, Inst Invest INCLIVA, Fdn Invest, Hosp Clin, E-46010 Valencia, Spain
[2] Univ Valencia, Hosp Clin, Urol Unit, E-46010 Valencia, Spain
[3] Univ Valencia, Sch Med, Dept Physiol, E-46010 Valencia, Spain
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2013年 / 13卷 / 01期
关键词：
angiogenesis; anti-angiogenic therapies; prostate cancer; review; CHALLENGES;
D O I：
10.1517/14712598.2013.733366
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Prostate cancer (PCa) is the second most common type of cancer among men in Western societies. Once in the castrate-resistant metastatic setting therapeutic options are limited. The importance of angiogenesis in the progression of PCa has been widely reported providing a rationale to test anti-angiogenic compounds for PCa treatment in clinical trials (CTs). However, in spite of the promising results shown in preclinical models and some anti-tumor activity observed in CTs, to date, no angiogenic inhibitor has been approved for use in PCa. This editorial outlines the latest clinical evidence regarding anti-angiogenic therapies in PCa treatment.
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页码：1 / 5
页数：5
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