Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis

被引:2
|
作者
Padilla-Benavides, Teresita [1 ,2 ]
Reyes-Gutierrez, Pablo [1 ]
Imbalzano, Anthony N. [1 ]
机构
[1] Univ Massachusetts, Dept Biochem & Mol Pharmacol, Med Sch, Worcester, MA 01605 USA
[2] Wesleyan Univ, Dept Mol Biol & Biochem, Middletown, CT 06459 USA
来源
BIOLOGY-BASEL | 2020年 / 9卷 / 07期
关键词
myogenesis; chromatin remodeling enzymes; cell signaling; SWI; SNF; SKELETAL-MUSCLE DIFFERENTIATION; ACTIVATED PROTEIN-KINASE; CELL SELF-RENEWAL; P38; MAP-KINASES; GENE-EXPRESSION; SATELLITE CELL; MITOTIC REPRESSION; STEM-CELLS; TRANSCRIPTION FACTORS; PROGENITOR CELLS;
D O I
10.3390/biology9070152
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Myogenesis is the biological process by which skeletal muscle tissue forms. Regulation of myogenesis involves a variety of conventional, epigenetic, and epigenomic mechanisms that control chromatin remodeling, DNA methylation, histone modification, and activation of transcription factors. Chromatin remodeling enzymes utilize ATP hydrolysis to alter nucleosome structure and/or positioning. The mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) family of chromatin remodeling enzymes is essential for myogenesis. Here we review diverse and novel mechanisms of regulation of mSWI/SNF enzymes by kinases and phosphatases. The integration of classic signaling pathways with chromatin remodeling enzyme function impacts myoblast viability and proliferation as well as differentiation. Regulated processes include the assembly of the mSWI/SNF enzyme complex, choice of subunits to be incorporated into the complex, and sub-nuclear localization of enzyme subunits. Together these processes influence the chromatin remodeling and gene expression events that control myoblast function and the induction of tissue-specific genes during differentiation.
引用
收藏
页码:1 / 18
页数:18
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