Hydrolytic dynamic kinetic resolution of racemic 3-phenyl-2-oxetanone to chiral tropic acid

被引：3
|
作者：
Kawasaki, Midori [1 ]
Shirai, Takahiro [2 ]
Yatsuzuka, Kenji [1 ]
Shirai, Ryuichi [1 ]
机构：
[1] Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, 97-1 Minamihokotate, Kyoto 6100395, Japan
[2] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, 1-2-3 Kasumi,Minami-ku, Hiroshima 7348553, Japan
来源：
RSC ADVANCES | 2024年 / 14卷 / 09期
关键词：
DERIVATIVES; SERINE; ESTERS;
D O I：
10.1039/d3ra08594e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tropic acid was synthesized in a good yield and with high enantioselectivity (81% ee) under non-biphasic conditions via the novel hydrolytic dynamic kinetic resolution of racemic 3-phenyl-2-oxetanone (tropic acid beta-lactone) in the presence of a chiral quaternary ammonium phase-transfer catalyst and strongly basic anion exchange resin as the hydroxide ion donor. The hydrolytic dynamic kinetic resolution of racemic 3-phenyl-2-oxetanone using a chiral PTC and water-free basic anion exchange resin as the hydroxide ion donor was achieved.
引用
收藏
页码：6121 / 6126
页数：6
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