The NLRP3 inflammasome as a target for sensorineural hearing loss

被引：16

作者：

Gregory, Grace E. ^{[1
,2
,3
]}

Munro, Kevin J. ^{[4
,5
]}

Couper, Kevin N. ^{[2
,3
]}

Pathmanaban, Omar N. ^{[1
,2
,3
,6
]}

Brough, David ^{[1
,2
,3
]}

机构：

[1] Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Neurosci,Manchester Acad Hlth Sci Ctr, Manchester, England

[2] Univ Manchester, Geoffrey Jefferson Brain Res Ctr, Manchester Acad Hlth Sci Ctr, Northern Care Alliance NHS Grp, Manchester, England

[3] Univ Manchester, Lydia Becker Inst Immunol & Inflammat, Manchester, England

[4] Univ Manchester, Manchester Ctr Audiol & Deafness, Sch Hlth Sci, Manchester, England

[5] Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, England

[6] Salford Royal Hosp NHS Fdn Trust, Manchester Ctr Clin Neurosci, Dept Neurosurg, Salford, England

来源：

CLINICAL IMMUNOLOGY | 2023年 / 249卷

基金：

英国医学研究理事会;

关键词：

Sensorineural hearing loss; Inflammation; Cochlea; NLRP3; inflammasome; Interleukin-1;

D O I：

10.1016/j.clim.2023.109287

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sensorineural hearing loss is the most common type of hearing loss in adults and occurs due to damage of the inner ear caused by a range of factors including ageing, excessive noise, toxins, and cancer. Auto-inflammatory disease is also a cause of hearing loss and there is evidence that inflammation could contribute to hearing loss in other conditions. Within the inner ear there are resident macrophage cells that respond to insults and whose activation correlates with damage. The NLRP3 inflammasome is a multi-molecular pro-inflammatory protein complex that forms in activated macrophages and may contribute to hearing loss. The aim of this article is to discuss the evidence for the NLRP3 inflammasome and associated cytokines as potential therapeutic targets for sensorineural hearing loss in conditions ranging from auto-inflammatory disease to tumour-induced hearing loss in vestibular schwannoma.

引用

页数：5

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