Response to Immunotherapy in Sclerosing Epithelioid Fibrosarcoma: Case Report and Literature Review

被引：1
|
作者：
Koerner, Anna S. [1 ]
Zhou, Maggie [2 ]
Brook, Ashley [2 ]
Yoon, Sam S. [1 ]
Ganjoo, Kristen N. [2 ]
机构：
[1] Columbia Univ, Irving Med Ctr, Surg Oncol, Surg, New York, NY USA
[2] Stanford Univ, Sch Med, Hematol & Med Oncol, Stanford, CA 94305 USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 12期
关键词：
pazopanib; pembrolizumab; nivolumab; ipilimumab; sarcoma; sclerosing epithelioid fibrosarcoma; GRADE FIBROMYXOID SARCOMA; GENE; MARKER; MUC4;
D O I：
10.7759/cureus.50967
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sclerosing epithelioid fibrosarcoma (SEF) is an extremely rare subtype of sarcoma that appears histologically low-grade yet usually has a clinically aggressive course with a high rate of local recurrence and distant metastasis. However, these recurrences and metastases often occur years after initial treatment. Metastases can be to the lung as well as extra-pulmonary sites. In this case report, we discuss a patient who developed SEF in the deep soft tissue with metastases. This patient underwent checkpoint inhibitor therapy, with disease response. Thus, SEF is a sarcoma subtype with a unique tumor biology, and immunotherapy may be a promising avenue for treatment.
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页数：7
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