营养支持对肠道菌群与肠黏膜免疫的影响

被引：35
|
作者：
王继伟
王新颖
机构：
[1] 南京军区南京总医院解放军普通外科研究所
来源：
肠外与肠内营养 | 2017年 / 24卷 / 05期
关键词：
营养支持; 肠外营养; 肠道菌群; 肠黏膜免疫;
D O I：
10.16151/j.1007-810x.2017.05.013
中图分类号：
R459.3 [饮食疗法、临床营养学];
学科分类号：
摘要：
肠内营养(EN)有助于保持肠黏膜的屏障功能,维护肠黏膜的结构完整性,促进肠黏膜固有免疫和获得性免疫的产生,维持肠道菌群的平衡和多样性。肠外营养(PN)能预防胃肠道功能障碍患者进一步营养不良的发生,挽救危重症患者的生命,然而PN会增加危重症患者感染并发症的发生。全肠外营养(TPN)时肠黏膜免疫受损,肠道菌群(GM)紊乱,滋养性喂养能显著改善肠黏膜的免疫功能,促进肠道内稳态的恢复。GM紊乱加重肠黏膜的炎症反应,或将进一步加重肠黏膜免疫的损害。因此,全面理解营养支持、GM与肠黏膜免疫之间的相互关系具有重要意义。
引用
收藏
页码：310 / 313+317 +317
页数：5
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