Relevance of donor-specific HLA antibodies in hematopoietic cell transplantation

被引：3
|
作者：
Tran, Thuong Hien [1 ]
Heinold, Andreas [2 ]
Spackova, Magdalena [1 ]
Pham, Lien [1 ]
Stelljes, Matthias [3 ]
Dreger, Peter [4 ]
机构：
[1] Heidelberg Univ Hosp, Inst Immunol, Neuenheimer Feld 305, D-69120 Heidelberg, Germany
[2] Essen Univ Hosp, Inst Transfus Med, Essen, Germany
[3] Munster Univ Hosp, Dept Hematol & Oncol, Div Bone Marrow Transplantat, Munster, Germany
[4] Heidelberg Univ Hosp, Dept Hematol Oncol & Rheumatol, Div Stem Cell Transplantat, Heidelberg, Germany
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2024年 / 37卷 / 03期
关键词：
Hematopoietic cell transplantation (HCT); Donor-specific HLA antibodies (DSA); Luminex; Graft failure; Desensitization; HUMAN-LEUKOCYTE ANTIGEN; GRAFT FAILURE; HUMORAL THEORY; CROSS-MATCH; IMPACT; COMPLEMENT; EXPRESSION; RECIPIENTS; C1Q; LYMPHOCYTES;
D O I：
10.1016/j.beha.2024.101576
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Advances in hematopoietic cell transplantation have expanded the use of alternative donors such as haploidentical family donors or mismatched unrelated donors. However, donor-specific HLA antibodies (DSA) have been recognized as a significant risk factor of primary graft failure after HLA incompatible transplantation. Therefore, screening for HLA antibodies and taking DSA into consideration in the process of donor search play an increasingly important role in donor selection. If an HLA compatible donor is not available, desensitization may enable a successful transplantation. In this review, we describe the currently most widely used methods for HLA antibody detections including their pitfalls. In addition, we summarize the results of the studies on the impact of preformed DSA on transplant outcomes and their treatment options. Many more and larger studies are needed to clarify laboratory issues as well as immunological and clinical aspects in the management of DSA.
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页数：12
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