Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction

被引：4

作者：

Hu, Yangnan ^{[1
,2
]}

Fang, Le ^{[3
]}

Zhang, Hui ^{[1
]}

Zheng, Shasha ^{[1
]}

Liao, Menghui ^{[1
]}

Cui, Qingyue ^{[1
]}

Wei, Hao ^{[4
]}

Wu, Danqi ^{[1
]}

Cheng, Hong ^{[1
]}

Qi, Yanru ^{[1
]}

Wang, Huan ^{[5
]}

Xin, Tao ^{[6
,7
,8
]}

Wang, Tian ^{[9
,10
]}

Chai, Renjie ^{[1
,2
,11
,12
,13
]}

机构：

[1] Southeast Univ, Jiangsu Prov High Tech Key Lab Biomed Res, Dept Otolaryngol Head & Neck Surg, Sch Life Sci & Technol,Zhongda Hosp,Adv Inst Life, Nanjing 210096, Peoples R China

[2] Nantong Univ, Coinnovat Ctr Neuroregenerat, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China

[3] Jilin Univ, Dept Neurol, China Japan Union Hosp, Changchun, Jilin, Peoples R China

[4] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Otolaryngol Head & Neck Surg, Jiangsu Prov Key Med Discipline,Med Sch, Nanjing, Peoples R China

[5] Sun Yat Sen Univ, Affiliated Hosp 8, Shenzhen 518033, Peoples R China

[6] Shandong First Med Univ, Affiliated Hosp 1, Dept Neurosurg, Jinan, Peoples R China

[7] Shandong Prov Qianfoshan Hosp, Jinan, Peoples R China

[8] Shandong First Med Univ & Shandong Acad Med Sci, Med Sci & Technol Innovat Ctr, Jinan, Peoples R China

[9] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, Stanford, CA 94305 USA

[10] Cent South Univ, Xiangya Hosp 2, Dept Otolaryngol Head & Neck Surg, Changsha, Hunan, Peoples R China

[11] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Chengdu, Peoples R China

[12] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China

[13] Capital Med Univ, Beijing Key Lab Neural Regenerat & Repair, Beijing, Peoples R China

来源：

SMART MEDICINE | 2023年 / 2卷 / 04期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

drug delivery; electrical stimulation; gene therapy; hearing reconstruction; organoid; EFFICIENT GENE-TRANSFER; PLURIPOTENT STEM-CELLS; INNER-EAR ORGANOIDS; DRUG-DELIVERY; ELECTRICAL-STIMULATION; HAIR-CELLS; COCHLEAR IMPLANTS; SUPPORTING CELLS; ENABLES SAFE; NANOPARTICLES;

D O I：

10.1002/SMMD.20230021

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hearing impairment is a global health problem that affects social communications and the economy. The damage and loss of cochlear hair cells and spiral ganglion neurons (SGNs) as well as the degeneration of neurites of SGNs are the core causes of sensorineural hearing loss. Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies (including gene therapy and cochlear organoids) and biomedical engineering technologies (including drug delivery, electrode coating, electrical stimulation and bionic scaffolds) in the field of hearing reconstruction are presented. Moreover, we summarize the challenges and provide a perspective on this field. Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies and biomedical engineering technologies in the field of hearing reconstruction are presented. Finally, the authors summarize the challenges and provide a perspective on this field. image

引用

页数：14

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